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More on Telomeres Telomerase Supplements and Cancer

I have written a ton on these topics before and I refer you to here for more background.

Briefly:

Telomeres are small segments of DNA at the end of every chromosome. They function like biologic time clocks determining when a cell will die. They are very sensitive to life style, toxins, stress, diet, supplements and nutrition, sleep deprivation and sedentary behavior.

Of the half dozen or so supplements that make claims to influence your telomere length, only TA-65 has any human data that suggests efficacy..

There is also an ongoing debate about the role of telomeres and telomerase in cancer which spills over needlessly into the supplement discussion.

Here that is in a nutshell:

Some scientists believe that telomere shortening and cell death is “anti-cancer” because a cell with short telomeres is more likely to have genetic mistakes encoded in its DNA.

Other scientists believe that restoration of telomere length may foster repair of the genome in much the same way that fixing “cancerous mitochondria” may revert the cell back to health. I am one of those and I base my feelings on the work of Maria Blasco who showed that increasing telomerase levels extended lifespan in mice without any increases in cancer incidence. I also postulate that all other areas of cellular aging had to improve such as mitochondrial function, intracellular junk clearing and epigentic marks or the animals could not have lived longer.  Sadly the study was not powered to “prove “ that but I sincerely doubt you could have an animal live longer without at least arresting those problems if not reversing them.

Almost all human cancers have short telomeres on average.  More importantly it may not take an average drop in telomere length to cause or facilitate cancer. More likely a few critically short telomeres on the “wrong” chromosome are enough.

The reason we do not yet have an answer is because the technology that is used in many studies to assay telomere length is not capable of giving us that data. As more and more people use the Life Length assay we will get more data.  At some point I hope the scientific community will universally switch over the way many anti-aging docs like me have.

Approximately 85% of human cancers deal with short telomeres by massive increases in the enzyme telomerase.  I have to say it: that means that 15% do not and they use a non-telomerase based mechanism to extend their telomeres.

This has led some people to worry about increasing telomerase with supplements.  Won’t this increase the risk of cancer or worsen a cancer if you have it?

Not likely to both statements.  Cancerous transformation is not and never has been dependent on telomerase. Once you have cancer the cancer will hijack telomerase for its own purposes to a degree that makes adding a telomerase activator inconsequential.  Indeed several clinicians have added things like TA-65 to their cancer patients’ routines to try and preserve the health of the immune system which universally takes a pounding from both cancer and cancer treatments.

This approach remains unstudied.

Here is another related observation.  First cancers beget second cancers. There is now growing evidence and interest in this linkage.  It appears that the shorter your telomeres are when you get your first cancer, the more likely you are to get a recurrence.  The problem is the timing of the studies has usually been after treatment so no one knows if the short telomeres were the result of “bad luck” as in you were born with shorter telomeres, or whether they were the result of the chemo and radiation these people got during treatment.

So we are left with a very basic notion you have heard before: Take care of your Telomeres!!!!

I offer a few options for you here:

TA-65

Telomere Edge Packs

Ultra 85 Fish Oil

I am one of those who feels very strongly about these associations and I am not willing to let a chance go by to influence them.

You must decide for yourself.

Best,

Dr Dave

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The Ketogenic Diet Part 5 What I learned and what you should know!

The best way for me to cover all the stuff I want to tell you is in simple bullet point form and that is what I am going to do. But first let me say one thing that is critical: If you are a healthy person this diet is not going to pose any serious risks to you.  That said run it by your own personal health care professional before you try it. So let me start the bullet points with a few “safety issues”

  • Ketosis is not Ketoacidosis. Ketosis is not dangerous. Your body can easily run on ketone bodies for a lot longer than you would think-possibly forever- as long as the nutritional makeup of your diet and the number of calories is sufficient to sustain you in healthy condition. Ketoacidosis happens to insulin dependent diabetics and in some less frequent cases to others. Most Type 2 diabetics will not have ketoacidosis but if you are a Type 2 Don’t try this without strict ongoing (like all day everyday) medical supervision from a qualified professional. Or at least get the blessing of yours before you do this!
  • You have heard me mention “starvation range” when referring to ketones of 4 millimoles and higher. This is a somewhat arbitrary definition but these ranges require sever calorie restriction.  Your average Ketogenic Diet will not get you to these ranges and you may not need them to “treat” certain illnesses.  I chose to go Calorie Restricted to try to fill the 2 main recommendations of the CRKD for “cancer prevention” * low blood sugars and high ketones to starve cancer cells and preserve normal ones.
  • Isn’t starvation unhealthy?  For short periods of times no. How short? Well 7 days is no big deal and if you look at the numbers I was only “there” for about 4 days out of the total.  Short term starvation may be just the thing to recycle sick mitochondria via autophagy (look it up!) and sick cells via apoptosis (you’ve heard me explain that one before too so look it up as well!).
  • Isn’t hypoglycemia dangerous!!!  Answer: it depends how you got there.  If you took too much insulin or skipped a meal on your oral anti-diabetic meds you got there artificially and had no time to generate alternate fuels e.g. ketone bodies then it’s dangerous. If you got there the way I did with gradual calorie restriction and you are generally healthy you will not suffer any symptoms from hypoglycemia because your body will have plenty of ketones to run on alternatively. So using this diet to induce hypoglycemia is not dangerous provided you to it the way I did or follow some recommended guideline.

 

Ok now on to some cool observations:

*Fish oil Doses: Because there was so little food intake and specifically almost no Omega 6 fat intake there was no need to hit the fish oil hard. One to three caps every other day was plenty enough to keep the blood flowing easily for my finger stick checks of sugar and ketones.

*In Dr Seyfried’s book he recommends avoiding caffeine altogether and no strenuous exercise- just walking!  I did not obey those commands for various reasons but I can tell you the amount of coffee required to wake up when you are not eating anything goes way, way down.  A 6 ounce cup would be reheated several times throughout the day and still have some left when I went to bed.

You will notice my blood sugars were very low on some occasions and much closer to normal on others. Generally this is the effect of exercise which does several things that are actually shared by caffeine consumption.

First it bangs on your adrenal glands and stimulates them to release “adrenergic” (stimulant) chemicals. This drives up our blood sugar even when there is little or no sugar in your diet.

Initially this comes from stored liver glycogen but that lasts hours not days so the only other reasonable source is gluconeogenesis* This means your body is going to breakdown that hard earned muscle you put on in the gym to keep your blood sugar up!  Remember how I told you weight loss was not the primary goal of this experiment?  Well body building sure as heck wasn’t either!

So the further you go into ketosis the more muscle you are going to lose.

OK now some final observations:

  • Mood and mental function: Although one or two people might disagree I did not notice any changes or moodiness at all.  I felt great and great about myself most of the time LOL! There were moments when my brain did not want to tackle any complex tasks or mental gymnastics but this was not all the time.  I found this to be more a function of high ketones than low blood sugar.
  • The one kinda creepy aspect of the whole thing that really hit me during the hypoglycemia and big time ketosis periods was an eerie feeling that it was ok to keep starving.  Almost like they say freezing to death is not so bad. I just felt like I could keep this up forever. Fortunately my first spoon full of high carb sugary dried fruit “healthy” granola knocked me right back into reality LOL! Yum does my body love SUGAR!!!
  • I “failed” to achieve the constant low blood sugars recommended because I refused to give up my exercise routines which would be considered “intense” under the circumstances.  This was personal choice and a matter of curiosity as well.  I did notice I tried a little bit sooner than usual and occasionally skipped the last set or cut a kilometer off a run but in general my performances were on par and on the last gym visit better than ever!
  • Caffeine and fish oil can be reduced because they will be more effective in the face of reduced calorie intake and absorption will be faster. Do take your multi vites though  as you can start missing critical things quite fast.
  • I needed to sleep more. Indeed I would say I slept a lot more soundly than usual easily grabbing 8-9 hours of uninterrupted sleep when possible versus my usual 7. Again reduced caffeine intake may have played a role but I am not a huge user to begin with.
  • I was almost NEVER HUNGRY during this diet.  I am not 100% sure but I have to assume it is the magic of ketosis as an appetite suppressant.
  • I was really surprised at how little my metabolic rate changed with this diet. Even using the accurate Body Gem I was running a resting metabolic rate of just over 2000 calories when in full blown ketosis and having lost almost 10 pounds. Bottom line ketones are an effective fuel for your body and can maintain your caloric needs just fine thank you!
  • I learned how much of my own eating was “habitual” just used to eating at a certain time and making certain food choices which are actually generally healthy but often high in carbs- like certain fruits.
  • I learned that for me personally Carbs Are the ENEMY. They stimulate my appetite and my cravings and they pack on calories fast. I learned this 4 years ago when I was full bore Paleo for the better part of a year but even this short stint brought that message home in a big way.
  • I learned that it is actually very hard to keep your carb intake below 30 grams since even high protein foods have some carbs.
  • Now here is the kicker: I learned it is easier for me not to eat all together than it is to manage carb intake and “eat healthy”.  I suspect like all habits the carb habit will take some time to kick and it will always be hovering around.  It is harder for me to control my carb intake by eating “just the right amount” than it is to avoid them altogether. I am still processing this fact!

My final thoughts: This was far easier than I thought but you definitely need to have the right mind set and discern “boredom eating” from true hunger. I was not ever able to get to water only even for 24 hours and that will be a challenge I undertake in 3 to 6 months when I do this all again. For me there would be a huge difference between even 300 calories and a little flavoring than nothing but water especially since metabolically I was able to achieve pretty much the same thing. I cannot imagine exercising with zero calorie intake over a couple of days and I am not willing to give up exercising even for a week at this point!

I think overall the effects of this little dietary experiment were totally positive and there will be some long lasting good things from learning about what makes me eat and how certain foods control my behaviors more than others!

As a final bit of good news, by the time you read this I will either have interviewed or be about to interview Dr Thomas Seyfried himself!  I can hardly wait!!!!

A thinner leaner more carb free Doc!

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TTAGGG You’re It! Stress, Disease and Telomere Length

The repeating sequence of the Telomere-TTAGGG has proven to be a gold mine for determining biologic age ( how old your body is acting!) and disease prognosis ( how bad you are likely to get something) as well as the effects of stress.

A recent study on the effects of racism on the telomere length of black men was the latest to show how social stress can affect longevity.  I have concerns about how the study was done but I think it makes sense to say that this kind of stress is detrimental to anyone’s health no matter what race or color.

This study builds on previous studies done in orphans who grew up with universally shorter telomeres than non orphans,  and the effects of stress on caregivers responsible for sick children.  All of these situations lead to more rapid aging and faster decline.  You can bet being sick in general can shorten your telomeres and your life.

This was shown by another study involving men between 50 and 75 who were admitted with ACS, acute coronary syndrome. Basically they were on their way to having a heart attack and no doubt some of them did.  The ones with the shortest telomeres did worse.

This study echoes the now famous Farezeneh Far, Blackburn study that showed that Omega 3 (fish oil) levels were protective of telomeres in heart disease.

So it seems everyone is linking just about everything bad that can happen to you to short telomeres and everything good to long telomeres.

It would be a good time for me to mention that other diseases of aging like Cancer and Alzheimer Disease ( yes they dropped the ‘s!) are also linked to telomere length in terms of incidence and severity.

Now there is still a lot of disagreement among researching scientists as to whether telomere loss is actually all that important in aging.  This pretty much depends on what their pet project is and where their grant money comes from.

I have a simple ( my PhD colleagues would say simplistic!) way of explaining this. My friend Maria Blasco did a study recently that showed that turning on telomerase extends life span in adult and old adult mice.  That was the end point of the study.  There are many other people out there looking at things like intracellular junk (lipofuscin) mitochondrial function, calorie restriction, sirtuin proteins and mTOR inhibitors.  None of these strategies have been shown by themselves to lengthen life although some of them seem to improve health.

I am certain that ALL of these things were improved by telomerase activation or the mice would not have lived longer.  You can’t live longer with declining mitochondria, abnormal proteins and increasing intracellular junk.  It’s simply not possible.  But because these things were not specifically measured common sense takes a back seat to scientific skepticism.

Here’s the thing: They would rather remain skeptical than investigate these questions probably because their grand money does not include answering these questions.  It does involve protecting their source of income for their pet project however.

Here’s another thing: as I said above Telomerase Activation seems to be the only current feasible way to extend life in mammals.  The folks spending time on all that other stuff have been unable to demonstrate increased longevity AND healthspan.

Want it to be even more simple?

I will quote that bastion of American Health who brought us the great Dr Oz.

Yes, I am talking about Oprah who said “I want long telomeres!” She should be on TA-65!

You probably should too!

I am entering year 5 with nothing but positive improvements in both telomere length and % of short telomeres. Both are going the right way for decreasing biologic age.

What is youth worth to you?

Doc

PS what I have said here is especially important if YOU are under constant or severe stress, get sick a lot or have a family history of one of those nasty diseases above!

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New Year’s Resolution vs. New Year’s Revelation

Today’s departure from the usual was sparked  by a question sent in by one of Dr Dave’s Best newsletter readers.  By the way if you are not one of them you should be since it is yet another way I keep my people up to date on all things anti-aging along with my myth busting and of course the latest developments.

The question was an interesting and probing one:  “Dr Dave what are YOUR New Year’s Resolutions, and how are you doing with them?”

At first I though, “That’s a bit forward! Isn’t it!”  but then I realized I did have some important info to share with you in that regard.

I have continued to simplify my life and I encourage you to do so.  Each year I hone in on what is most important in my life.

I have narrowed it down to 3 major things and almost all of my resolutions have to do with those things.

They are:
#1 My Health  I hope its not too big of a surprise that my own health is paramount to just about everything else I do. I know of some very famous people in my field both internet types and non internet types who are just flat out sick.  They don’t look happy and they certainly don’t look healthy, no matter how many millions of readers they have.  It always struck me as strange that a person can’t look at someone and say, “Wow they can’t be practicing what they preach or if they are its the wrong stuff!”
In my book if you walk the walk you look great feel great and are a beacon for people who are trying to stay young for as long as possible.  And a wonderful by product of that is you are happy most of the time and people know it!

I think my hero in that department was Jack La Lane!

Now in terms of simplifying how I look at my health my overall approach has been and is: do what works and always keep the long exciting and active future you have in mind as the end goal.

A few of the modifications on previous habits are: Get leaner and eat cleaner even on the road. Exercise MORE when traveling not less.  And a very simple one: eat less calories every day.

#2 Take care of the people I love and those who love me.  Now is a good time for me to remind you: I do what I do for myself and the ones I love. Now as self centered as that may sound frankly its the kind of integrity you should expect from anyone in my position. That is also the way I always practiced medicine. If I would not want me for a doctor or me taking care of my mom then I do not belong in the profession. That attitude has carried over to:

#3 My business: I once spent a little time with one of the top internet guru docs on the planet. Everything I heard was about money and business.  Everything.  Everything that was written and sent to that list was designed to get more business.  Now I admire a certain degree of business savvy but when people are actually doing what you tell them to and spending their hard earned dollars on your stuff I think they would like to know what you personally do and take and how you can help them before they know you are always helping yourself independent of how it may truly affect them.

On occasion that means saying you disagree with the party line on something. Now as I have learned many times over, that upsets people and actually negatively affects your business.  But there are truth seekers out there who are genuinely looking for answers and are willing to at least listen to someone who speaks their truth, backs it up and lives it.

I am not sure if you follow me on Facebook at all but that venue is where I SHOW what I am doing including all the “personal Guinea pig stuff” I am vetting for you. Once again it helps me and keeps me on the cutting edge of my personal space in the world: anti-aging.
It also helps you because you find out about it first from someone who has “been there and done that”. In the next few weeks I will be starting an experiment on myself with 2 other brave souls that I hope will be a revelation.

The resolution behind it was this: Speed up the process of new discoveries in human anti-aging medicine.

Another revelation I have had: my business is important to me because it is me. It feeds #2 above and of course #1 every single day.

Now I want to share a personal Revelation with you that has helped me immensely with all of the above because it has allowed me to find guidance from places far bigger and wiser than I.

Here it is: Let Go of Outcomes! Ask for what you want with faith and positive expectation and then let it go.  You will be shown the way. In the process you will be doing something else magical: Making Space. By quieting your mind and not trying to force, will and control everything you will have space to enjoy the moment and see and hear things around you that will help you make all of your Resolutions come true, and much much more.

If you need help with intuition and creativity or even just more brain power here is my secret It is not the ONLY reason I get some much done, but it is a huge help.

And everyone needs some of that.

What have you done so far and what are you going to do?
I hope its everything and more that you want to do.

Best, Dr Dave

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New Cancer Pathway Involves Telomeres

Drum roll and trumpets please!  A new cancer causing pathway has been found. It involves telomeres of course.

I bring it to your attention though, not for what it has shown us, but for how it its marketed. You see even scientists know they stand a better chance of getting recognition if they blow the trumpets and role the drums.  That means press releases and social media nonsense that is written by non scientists.

Now don’t misunderstand me. I give them the same “get out of jail pass” I often claim: “I didn’t make this world, I just live in it!”

Still as your source of the truth about all things telomere related, especially when it comes to your health and your understanding, I consider it my calling in life to make sure you are not blown all over the map by media hype and internet nonsense.

So let’s go over a few facts:

1)      Fact one: Telomerase does NOT CAUSE CANCER. Every time I write this I hope it is my last but that is never the case it seems.  85% of human cancers turn on telomerase somewhere in the process of becoming cancer. In the one or two cases we are clear on its actually one of the last steps ( villous adenoma to colon cancer) but cancer genetics are a diverse thing and no one knows the exact sequence that mutations happen in all cancers. There is a growing contingent of people out there who feel that contrary to 65 years of research, cancer may not even be a genetic disease. When telomerase is expressed in cancer it can be a) mutated, b) amplified c) transposed d) any other genetic abnormality that can lead to over expression! The key is to understand that things happen to cause cancer long before telomerase expression shows up to immortalize the cells, and that those things lead to the loss of normal control of many genes and their end products. Telomerase over expression does not seem to cause cancer by itself in the absence of other major changes.

2)      Telomerase is required for ultra long longevity and gene integrity in cells. Two of the best examples are germ cells (the things that become sperm and eggs) where there is a large amount of telomerase expression and stem cells where there is less. The later fact is probably one of the main reasons stem cells age albeit at a slower rate than the rest of our cells.

3)      There are normal “cell cycle check point” mechanisms that have been known for some time now that need to be bypassed in order for cancer to take hold.

4)      Longer telomeres are associated with a cleaner genome (fewer mutations) cleaner mitochondrial cell powerhouses (fewer mutations better function and better ability to make new mitochondria) and a lower and less sever incidence of cancer.

5)      While most cancers turn on telomerase there is another way for cancer cells to lengthen their telomeres and survive that does not involve telomerase.  This generally is reserved for the badest of the bad in terms of genetic instability (actually if I am being scientifically correct its “genomic instability” but you know what I mean!). This mechanism is called ALT.

6)      The ability to divide endlessly either using telomerase or ALT is one of the hallmarks of human cancer.

That brings me to the “latest findings”.

One Dr Jan Karlseder of the Salk institute discovered one of the mechanisms behind the ALT method of lengthening telomeres. Dr Karlseder found a protein called ASF-1 that drops down to zero and triggers cells in culture to use the ALT mechanism to lengthen their telomeres.

All well and good but here are my gripes.

Cancers in real life have measurable levels of that protein. It does not drop to zero in ALT driven cancers.

The super irritating insinuation that I see in all such articles “This will help us develop drugs to fight cancer”  is present here. Cancer drugs are expensive, Cancer drugs are deadly, Cancer drugs divert research away from, gasp, cancer prevention which no scientists is willing to admit they believe in. And there is no money in prevention. If you think this is a joke mark my words a cancer preventative treatment that is not a patentable drug will not be released until a drug company owns it. At least not over their dead bodies. That said most of the quacks who claim to have cured cancer and have been jailed for such statements actually do belong there!

Next, the press release is entitled “Cancer Causing Pathway Explained”.

Now I bet this was the sole concoction of the press release company. I do not think that such smart scientists would allow their discovery to be called named this way. The ALT pathway does not cause cancer, it is probably one of the last or later pieces in the puzzle.  By naming it this way they are propogating the myth that telomeres are responsible for cancer.

Next there is the usual talk of “balancing cell aging with risk of cancer” . This implies that we get old and die to prevent cancer from killing us. After I am done with the LOL ing I want to remind everyone that old cells, senescent cells seem to excrete inflammatory and yes cancer causing signals. For this reason it seems nonsensical to propose that getting old protects us from cancer. Especially when cancer is a disease of aging in 95% of all cases!

Summing it up, I would say it this way: We are barking up the wrong tree. Telomerase and telomere lengthening are cancer protective under normal circumstances. Guys you have to keep looking for the chicken that is laying the egg not examining the ingredients in the omelet!   This is also the reason I am intrigued if not convinced of the metabolic cause/component of cancer.  The genetic stuff leads nowhere but to an ever increasingly large ‘room full of pathways’ that has no end. Great for researchers and crappy for people who have or want to prevent getting cancer.

In 12+ years of research I can tell you two things with surety. Walk around with “high” omega 3 levels and keep your telomeres long anyway you can.

There are quite a number of famous scientists who are doing just that even though they will not say it in front of their peers for fear of ridicule. Me? I don’t care who ridicules me. I refuse to sit on my ass and get old when there are real answers to slowing and eventually stopping the process.

I will make this prediction. Classic science just like classic medicine will not make major breakthroughs in aging and health span. They will trumpet their findings just like the article above but the real breakthroughs will come from people who are actively seeking the answers and doing something about it every day .

That is you and me my friend!

Best, Dr Dave

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Krill better than fish oil- more chicanery

A recent a study published in the journal Lipids in Health and Disease my favorite topic was examined. That topic you may have guessed is the ratio of Omega 6 inflammatory fats versus Omega 3 anti-inflammatory ratio. I have harped on and on about this for many years because it is the most important measure of how YOU are doing with your fish oil consumption. In my recent teleseminar I detailed the results of over 150 tests that I did. Like I have told you before I do my own research on stuff I think is important. I don’t just rely on internet nonsense or marketing hype which sadly is what most of it is.

Which brings me to the next point.

There is a battle going on for market share in Omega 3’s. This is not surprising considering their importance of Omega 3’s.
Here are the combatants.

Omega 3 fish oil manufacturers which include Ethyl ester “natural triglyceride” fish oil which is pretty much straight out of the fish, and finally the so called re-triglycerided “fish oil”  and a real anomaly since this molecule does not exist in nature at all.

Today I want to focus on krill and debunking some of the marketing nonsense and hype that goes on.

Please note this is only a short list of the most frequently used BS arguments on the internet. I am not against competition I am against deceptive tactics and as you will see there are plenty.

Here are they typical nonsense internet claims you will here and the truth

1) Krill is better than fish oil. The latest study shows an improved Omega 6/3 ratio with krill over fish oil. In the past Acker Biomarine the largest krill manufacturer on the planet funded a similar study. That study also showed an improved absorption on a mg per mg basis with no difference in clinical outcomes. Interestingly enough the folks at Acker were slick enough to pick a really crappy cod liver oil with only about 30% Omega 3 content. And they still could not say it was better. The most recent study Lipids Health Dis 12:178, 2013 was even more clever. Somewhere somehow they found a “fish oil” that was more omega 6 than omega 3. That was what they used for comparison, something that was guaranteed to show a positive result. Since this kind of fish oil had to be deliberately sought out and does not represent even typically available commercial fish oil I can only conclude this was deliberate chicanery meant to deceive people who do not know any better. How about this. I invite the authors to redo the study with my Ultra 85 I will donate as much as they need but they HAVE to publish the results. I will be waiting! I should also point out another thing. Last April there was a fatal explosion at the Neptune Krill plant in Canada. Hexane a volatile organic solvent that has been linked to cancer caused the explosion. Since Neptune makes only Krill I have to wonder what they use the Hexane for! I can only guess this is part of their extraction process. You decide whether this sounds like something you want to be exposed to!

2) The integration of krill into membranes is better than fish oil because it’s a phospholipid and mimics the membrane form more closely than any form of fish oil. This is actually true on a mg per mg basis. But they leave out the fact that commercial krill preparations only contain a total of around 300 mg of Omega 3 per capsule. They also leave out the fact that membrane bound Omega 3 still has to go to single chain EPA and DHA to be used for anything other than membrane activity. While membrane bound fatty acids are structurally important in ALL membranes including cell wall mitochondria and nuclear membranes. But anything else and believe me there is lots else (cytokines Resolvins Protectins all kinds of immune and hormonal modulators) all goes through single chain EPA and DHA forms. Ethyl esters are the closest format to that. Closer than 2 tailed phospholipids and much closer than the 3 tailed triglyceride forms.

3) Krill is pure because it’s small and comes from the pure Antarctic waters. What a load of BS that is. The krill I tested independently had lots of toxins and pollutants including 50X the amount of arsenic allowed in drinking water. Wanna guess which famous internet guru that everyone things so highly of is selling it? In addition the statement is true only if you look at single isolated organisms. Krill is tiny and it is at the bottom of the food chain. So its true it cannot accumulate much pollution. But when you concentrate hundreds of thousands or millions even to make one bottle then a little gets magnified and becomes a lot. Do you really think the people making these statements don’t know that?!

4) Fish is non sustainable therefore we should use krill. The Truth: Several krill fishing areas have been shut down because of eco system imbalances. Fish consumption is however stable now and for the foreseeable future due to appropriate fish and aquatic husbandry. In addition attempts to modify the food chain have led to such great things as Frankenfish the genetically modified salmon that grow huge and outcompete their wild type neighbors while providing more Omega 3 per pound. And my favorite GMO- plants modified to produce human form Omega 3’s, now looming on the horizon. Krill is certainly no more sustainable than fish and is more likely to affect more species because it is so low on the food chain.

5) Please show me one population based study on krill. I want that because the tiny little studies that are funded by Acker and Neptune completely lack the statistical power needed to draw any real conclusions and the conclusions they draw are “equivalence” not superiority in spite of the marketing hype. Truth: There is not one population of humans on the planet that lives on krill.

6) Ethyl ester fish oil is poorly absorbed. The truth is it is not “poorly” absorbed it is “slowly” absorbed so if you fiddle with your studies in the right way and check the absorption times at one hour you will see a difference. But the largest series of studies done with Ethyl Ester fish oil was called GISSI and have many times shown all the benefits these studies showed. They researchers there deliberately chose Ethyl Ester fish oil for it’s slower absorption curve for a reason. That reason is most people take their fish oil in the morning after they wake up. Most heart attacks statistically happen earlier in the morning. The slow steady 24 hour absorption curve of Ethyl ester fish oil covers the people better because it is still around at the time they need it most, 20 to 22 hours later! The results were unequivocal and included a 28% reduction in sudden death, 35% reduction in all cause mortality and similar reductions in cardiovascular and cerebrovascular deaths.

7) Here is what a recent review of fish oil formats concluded: “While the results with fish and fish oils have been not as clear cut, the data generated with the purified ethyl ester forms of these two fatty acids are consistent.” Read that last word CONSISTENT. There are no other Omega 3 formats that can show the same volume of data. Not krill not “natural triglyceride” not retriglycerided NONE!

8) Here is more from that same article EPA and DHA as ethyl esters inhibit platelet aggregability, and reduce serum triglycerides, while leaving other serum lipids essentially unaltered. Glucose metabolism has been studied extensively, and no adverse effects were seen. Pro-atherogenic cytokines are reduced, as are markers of endothelial activation. Endothelial function is improved, vascular occlusion is reduced, and the course of coronary atherosclerosis is mitigated. Heart rate is reduced, and heart rate variability is increased by EPA and DHA. An antiarrhythmic effect can be demonstrated on the supraventricular and the ventricular level. More importantly, two large studies showed reductions in clinical endpoints like sudden cardiac death or major adverse cardiac events.

9) Ethyl Esters are not found naturally in humans or in nature. Truth: Ethyl Esters are naturally occurring intermediates in the Omega 3 chain. This is often how other forms (phospholipid and triglyceride) become the single chain mediators they need to to create the Omega 3 effects against inflammation. In addition they are they main form of Omega 3 found in Calanus finmarchicus a kind of shrimp that inhabits the Northern Atlantic. So there goes that argument as well.

There is a reason you will not see well designed honest head to head studies comparing the effects of something like Ultra 85 to any of these other formats. All you will see and hear are people you never heard of claiming to be experts hawking their products. I do that too don’t I. But I design and chose my products based on science testing and what I would want for myself and my family.
If you knew what I know this is the only stuff you would consider ultra 85 and regular PG fish oil

Doc

PS If you want to learn more go to my telecom here.

References:
Ramprasath et al.

(Lipids Health Dis 12:178, 2013
Author: Peter D NicholsSoressa M KitessaMahinda Abeywardena
Credits/Source: Lipids in Health and Disease 2014, 13:2 “(Lipids Health Dis 12:178, 2013)”These conclusions are not justified and misleading. Considerable care is needed in ensuring that such comparative trials do not use inappropriate ingredients”

Metabolic Effects of Krill Oil are Essentially Similar to Those of Fish Oil but at Lower Dose of EPA and DHA, in Healthy Volunteers
Stine M. Ulven, Bente Kirkhus, […], and Jan I. Pedersen study funded by Acker Biomarine Please note the words “Essentially Similar” and this was using the lowest level fish oil they could find! This stud also noted an unexplained rise in inflammatory Omega 6 fatty acids with krill supplementation!
Vasc Health Risk Manag. 2006;2(3):251-62.
A review of omega-3 ethyl esters for cardiovascular prevention and treatment of increased blood triglyceridelevels.
von Schacky C.

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2013 The Year in Review

First let me wish the Happiest of New Years and a phenomenal 2014. I can tell you that if 2013 is any indication, 2014 will be spectacular.

And speaking of 2013 I want to give you a brief perspective on this passing year from Dr Dave’s Best point of view both in terms of accomplishments and some personal stuff as well.

As always I like to start with a broad associative allegory about something I have learned and something I have sought.

Several hundred years ago there was a brilliant French essayist named Montaigne. He wrote about many things in such a succinct fashion that I have often sought his counsel through his work during my adult life time.

One characteristic he wrote about struck a chord with me in recent years: Equanimity. I made it a point in my New Year’s resolutions to seek it out and I can tell you that after 2 years of “asking” I think I found it in recent months and will only build on it.

My version of Equanimity is being balanced and centered in the knowledge of who I am and what I am to do here on this earth. Because of it the ups and down, the ebbs and flows and the fractal nature of life and time are more easy to walk through on an even plane.

Sound complicated? Just think balanced no matter what comes your way and you’ll have it. Trust me it’s a good place to be.

It is also the thing that allows me to tell you with 100% certainty that you are going to enjoy this next year with me if you chose to do so because massive break throughs are coming.

But let’s not forget 2013, so here we go.

In the earliest part of the year and leading in from December 2012 we introduced RG Stem Cell Activating Serum.  At the same time we also introduced the newly revised and redesigned Telomere Edge Packs. Each represented a never before created achievement and brought the promise of telomere preservation and stem cell activation within the reach of everyone on the list.

In March I reintroduced a product I had been sitting on for over 2 years, Ultra 85 fish oil. The ‘world debut’ of the product happened 7 weeks later at David Wolfe’s Longevity Now Conference. The great ironies of this were two: first this is where the product was originally introduced 2 years prior but because of the production costs we could not yet sustain its manufacture, next UPS lost our entire shipment.  You might have guessed that we were able to figure out how to make the product affordable both to us and the public. You might not have guessed that even in its absence, we sold out of the entire batch that would have arrived and filled those orders from our warehouse stock a few days later.

Immediately upon my return I introduced our contest which you can still participate in.  I can recall having an epiphany when I asked, “How do I get people excited about this contest and wanting to participate?”  You see back in the day when I first started rewards and free stuff was all the enticement one needed. Now 13 years later people are jaded and over marketed on the internet and I bet if I promised a million dollar reward no one would even read it! So I decided to tell everyone who joins the contest the main reason I wake up every morning.  To do research on products that will improve your life.

That seemed to be enough to get people moving because they understood they would directly benefit from the effort.

Two months later I was in Canada coaching my sister on her first Canadian Death Race and by the end of the month I was in the company of one Laurel Sander OMD getting healed big time at a full-fledged cleansing retreat. You can see some pics from my most recent trip there a few weeks ago. Suffice it to say the healing took and after 3 years of lower than desired physical activity I am back to my old self again. Now understand this is the culmination of a lot of things I do.  If you have followed me for any length of time you know I ask a lot of my mind and body and I am happy to say it’s delivering again.

During this time I also had my telomeres measured several times in both peripheral white blood cells and in my stem cells.  The later results are part of one of the studies I am currently doing so I cannot divulge that info but my peripheral cells gained over 600 base pairs using 2 separate assays and my immune profile has improved dramatically as well- all from taking TA-65 and the Telomere Edge Packs.  Depending on what you want to use as a starting point I have reversed the aging process in this most important cellular compartment by anywhere from 6 to 10 years.  The remarkable thing is I see it and feel it in my mind, my body and my performance. I am getting YOUNGER!!!

Now the skeptics among the world have said, “OK big shot you talk a good game now let’s see the numbers!  Why won’t you show us the numbers?”  So in a rare bow to peer pressure I have decided that I will reveal all the numbers on their official report sheets so all the naysayers can shut up ( hint that will never happen no matter what proof I offer LOL). But I do ask one favor in return after I do this.  People seem to love to call me on my credentials which are in fact a matter of public record if certain skeptics would get off their lazy asses and do a minimal amount of research. Again it’s much easier and more authoritative to simply fire it off as a command and hope I jump when you say how high than it is to type in “google”. But I will do the work just this once but in return I ask the following: There are a lot of big named people out there that you trust just based on their web popularity. So ASK THEM TO PUT THEIR MONEY WHERE THEIR MOUTH IS AND SHOW YOU THEIR TELOMERE LENGTHS.   I can tell you that more than one of them has done the test and been angry and shocked that their results sucked! Ask them and you’ll get a bunch of BS excuses about how the test is not accurate. The test is deadly accurate but the way they live their lives and their own information is faulty in terms of your health and longevity.

There I said it. Now you figure out who I am talking about and demand the same accountability from them. And while you are busy waiting for what will never come I will remain totally transparent because your life and your decisions depend on it.

That brings us to the late summer early fall when the next RG products arrived from the lab: The Booster, The Cleanser and the Blemish Cream. If you have not seen the videos on these products they can be found here on YouTube.

Also available there is the complete teleseminar on omega 3’s. If you have ever been confused about everything you hear about fish oil this is a great way to get the real truth. The difference between this and the marketing hype is I show you the actual biochem texts, articles and the results of over 150 Omega 6/3 ratio tests I have done.  I have honestly never seen anyone else try to back up what they say this way. Pretty sure the reason is they can’t but you be the judge!

And while you are on YouTube you can see me getting my telomeres tested on several different occasions, testing Omega 6/3 ratios and reviewing the honest data on krill, triglyceride fish oil and generally debunking myths left and right!

From September through December the work you did during the contest paid off. I was able to do additional research on telomere length and stem cells which has never been done. It will be at least another 6 months before the results are in but I will be once again in Mexico treating myself in a few weeks. By being the guinea pig here I am doing the kind of research you should be demanding of any internet doc who claims he is pioneering and cutting edge.

The same stem cell team I employ for the research just gave me the preliminary findings on RG cell serum and booster and showed that we are increasing youthful collagen production in skin fibroblasts. I will have the final report out to you in January 2014.

I will also continue to test these products for stem cell activation.

Speaking of products I have at least 2 new ones slated for release in the next 60 days so stay tuned!

Now a little personal info.  I have continued to meet speak with and learn from the best and brightest on the planet and that continues to be reflected in my newsletters and blogs.

And that is a lucky thing for you and me!

Happy New Year!!!!

Doc

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The latest TA-65 Human Study results

Science is like Molasses… it flows slowly.

Ever since the 2010 human study on TA-65 was published I have been telling you about the “other half” of the data. I had access to it so I shared it with you but naturally the naysayers and skeptics said, “I’ll believe it when I see it!”

So here it is 3 years later! But before I repeat what I have been telling you let me tell you this:

I did not have to make any changes in what I said because the published study tells you exactly the same thing I have been telling you.  Nothing was “wrong” and nothing has changed!

As it has in the past the fact that I have been privy to information that has not been publically available is bound to upset people. This was best pointed out when one of my colleagues commented on our book, “The Immortality Edge” by saying, “Well you are Right Now but You were wrong when you wrote it!”

Once again he was commenting on the fact that I knew things that he and others did not. SORRY!

I have made it my business to be at the front of this field as many other people are at the front of their fields. Many of the same doctors that criticized me for publishing facts that were based on unpublished studies have inside information in their areas of expertise. This just happens to be mine!

Next I want to tell you there is a movement to equate cycloastraganol with TA-65. This is true and that is exactly what TA-65 is but it is not that simple. There is a difference between the format TA-65 is provided in. The “MD” is a micro dispersed format that makes it bioavailable. There are no studies that equate simple powdered Cycloastragenol that is available for $68,000 a kilo in the one market with the MD format. As a matter of fact no one has done Pharmacokinetic studies on any form of Cyclo except TA-65. I also have not seen any purity studies on these powdered products looking for toxins and contaminants so frequently found in imported raw materials!

As a matter of fact no one has done ANY human studies on ANY telomerase activators other than specifically TA-65 with the exception of Geron Scientist Calvin Harley who continues to develop other telomerase activators.

To say that Cycloastragenol in any form can be equated to the human results obtained with TA-65 is deliberately misleading and not accurate. Do the studies in people! Then you can make claims. And if you are claiming equivalency then do the head to head studies using TA-65 versus your product.

There is a reason people selling telomerase activation products are not doing human studies.  I do know of studies that were attempted and failed miserably of products that are now being offered as such. All I will say is the parent companies have backed off their rhetoric.

Ok in case you missed the last 3 years of my newsletters and blogs here is what the October 2013 published human study which was part 2 of the original human study said about TA-65 and the protocol that accompanied it:

Statistically significant:

  • Reduction in blood pressure
  • Increased Bone Density
  • Decreased inflammatory marker: Homocystiene
  • Decreased blood sugar
  • Decreased Insulin secretion
  • Impressively reduced cholesterol!

Along with the previously documented changes in the immune system and the reduction in short telomeres. I have been following my own telomere length and short telomere percentages now for the 4 years I have been on TA-65 and both have improved significantly.

More importantly I continue to feel and look younger!

The choices is yours but if you want the proof, you have only one choice: TA-65.

Doc

  • Please note the human studies above refer to a protocol that included a multivitamin. None of the ingredients in the multi have been shown to activate telomerase or lengthen telomeres but this remains the major criticism of the study. TA Sciences in now conducting a study using ONLY TA-65. While we have no reason to believe that the multi + TA-65 changed the properties of TA to Make it a telomerase activator when it was not one, and we have specific evidence that TA-65 does turn on telomerase and the other ingredients in the multi do not, it still remains a bone of contention for some scientists.

The randomized double blinded study now going on should shut those people up but it will take a year to complete and 1 to 2 years to go to publication.  Like I said, real science moves slowly which is why some people do chemical studies like chromatorgraphy and use them to influence your thinking. They are cheap fast but of little value in human biology!

Reference: Rejuvenation Res. 2013 Oct;16(5):386-95. doi: 10.1089/rej.2013.1430.

A natural product telomerase activator as part of a health maintenance program: metabolic and cardiovascular response.

Harley CB, Liu W, Flom PL, Raffaele JM.

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Telomeres and Cancer- More than just Length

Telomeres are our cellular biologic time clocks. They are found at the end of every healthy chromosome. It they are short that chromosome and the cell it lives in are headed for disaster. By disaster I mean,

1) Removal from the functional cell pool leaving you with fewer healthy cells to do their job.

2) Auto suicide where the cell blows up from the inside out also known as apoptosis- same result fewer healthy cells to do the job.

3) Cancer-that’s right cancer. An article in the prestigious Journal of the American Medical Association showed that short telomeres are equated to increased cancer incidence and increased cancer severity.

Bottom line message: short telomeres are bad for you

Ok let’s look at some more studies that reinforce the message.

In the October issue of Cancer Discovery a large group of men with known prostate cancer that was initially confined to the prostate gland were evaluated for telomere length in their tumors. Their findings confirm the importance of telomere length in both initial cancer treatment and its follow up.

They found that a variable telomere length or a wide distribution of telomere length when combined with short telomeres in the surrounding non cancerous tissue led to a higher likelihood of the prostate cancer metastasizing (spreading).

Men with this combination of telomere pathology had a 14X higher chance of dying in less than 10 years than men who did not.

Dr Dave comments:

First remember that prostate cancer is a very variable disease. The current recommendations for screen are far less aggressive than even 2 years ago because recent data indicates there is enough low grade disease out there that will not significantly shorten the life span of the men that have it that finding all the prostate cancers we can and diagnosing them and/or treating them is MORE likely to kill the patient or cause significant harm than letting men live out their lives with the disease.

If you look at the recommendations for things like mammograms chest X rays Pap smears and all manner of “routine screening” tests these have ALL changed in the past few years because we realize we did more harm than good by being super aggressive about looking for these diseases in low risk populations.

That said having a good indicator of the people we SHOULD watch closely when we do diagnose a disease is incredibly valuable for the use of our health care dollars and resources. Using telomere measurements of this kind could help us select the people who needed much closer and more aggressive follow up where the risk of things like biopsies or the expense of PSA blood testing is justified. It’s like using telomeres to tailor make the treatment and follow up plan.

As far as the “wide distribution” of telomere lengths be aware that this is common in many different cancers. In some cases it means that telomere length goes from ultra short to short. In other cases it means telomere length varies from short to actually being longer than normal. Much of the “lengthening” of telomeres is actually false or misleading in a sense because it occurs from telomere end to end recombinations or the so called ALT method. This ALT method is almost always a very bad sign because it takes massive chromosomal instability to allow this to happen. This means the chromosome is super damaged and the genome is very unstable, both hall marks of bad cancers.

The fact that the surrounding tissues had short telomeres suggests again genomic instability and weakened sick cells that are “acting weak and old” or senescent. This would mean tumor invasion would be almost invited into the surrounding tissue.

It also reinforces something I have written about many times before when discussing the various methods for measuring telomeres. I prefer the Life Length assay over all others because it measures the percentage of short telomeres. No other test can do this accurately for the individual. Short telomeres are the hallmark of sick dysfunctional old cells that are more likely to cause cancer and disease!

You should also know similar studies in breast and many other cancers as well as heart disease also link telomere length to prognosis. The day is coming when telomere length will be a routine part of staging most cancers.

But here is the most important thing: Staging a cancer is not a great thing. Not getting one in the first place is much better.

Many of us in the telomere field myself included believe that since short telomeres are an increased risk for cancer, longer healthier ones are potentially protective. We know that people and animals with longer telomeres tend to have longer life spans and longer health spans (the amount of their lives spent in a health state) than those with shorter ones.

This is why I am so aggressive about telomerase activators like TA-65 and telomere preservers like Fish oil.

I would rather hear I do not have cancer than be told what stage it is in!

Think about it and do more research and you will feel the same way too!

Dr Dave

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Still not Dead!

In mid-July a ridiculous poorly designed poorly done study was published by a “reputable journal” from the National Cancer Institute.  It associated “high Omega 3 intake” with a 70% increased risk of prostate cancer. It was published by one Dr T. Brasky and his research time and derived from a sub group analysis of another study called the SELECT Trail designed to look at the effects of selenium on prostate cancer risk.

In my blog “As I lay Dying” and the subsequent blogs after it I detailed how absurd the Brasky study was. I concluded that in my opinion the negative press was absolutely a deliberate ploy in the part of these researchers to get attention.

Sadly it worked.

For a while.

I remember one irate gentleman out there who engaged me on another web site basically saying that 3 well known experts including a nationally famous Urologist and a well-known Endocrinologist said it was dangerous and “did I think I knew more about prostate cancer than they did”.

I didn’t bother to answer at that point because it was pointless but here is the answer I would have given: “No I don’t know more about prostate cancer, but I know a hell of a lot more about Omega 3’s and fish oil than those bozo’s!”

So for about 6 weeks I stood as pretty much a lone voice for fish oil.

But I predicted in due time another study, a better designed study, a study that was actually asking a question instead of selling and agenda, would come out and refute any association and support the use of fish oil as a beneficial thing in prostate cancer.

This by the way is not rocket science. The positive studies on fish oil outnumber the negative 99.9 to1.

So a recent study from UCLA was just released that showed the combination of a low fat diet along with fish oil ( which is ALL fat by the way!) may help prevent recurrent prostate cancer and decrease its growth .

One comment the only role of eating a low fat diet in this disease and other diseases in my opinion is that it limits the amount of grain fed Omega 6 rich meat these men consumed. If they ate free range grass fed I think it would be of additional help.

One way to boost the Omega 3 ratio in the blood is to consume less of its opposite, Omega 6.

Restricting Omega 6 and increasing Omega 3 are critical to cancer prevention in everything I have ever read.

Which leads me to the final statement. I think the National Cancer Institute’s allowance of Dr Brasky’s study to be published was bordering on criminal.

Worse werethe statements he allegedly made recommending people to consume more Omega 6.

That advice will in my opinion actually increase your risk of cancer.

To all the internet guru’s, internet doctors, cowardly health care providers, news anchors and “experts” who immediately jumped on the “Fish oil may increase risk of Prostate Cancer” where are you now?

Probably onto some other trending story that will boost your sales and your ratings.

 

To the guy who told me I was wrong and he was right because he had expert opinion on his side, I am waiting for your letter of apology.

I have yet to see one retraction from anyone.

To all my faithful readers, clients, customers and patients who had learned enough from me to know this whole thing was bogus I say congratulations for not being snowed by “public opinion”.

If anything, after 12 years you know I tell you the truth even when it is not popular. I don’t side with the traditional allopathic agenda. I don’t side with the Holistic or Alternative agenda. I routinely disagree with “experts” on both sides of that fence.

Me? I side with the truth. And believe me there is truth out there.

That truth is all you and me will ever need to live our best lives!

With deepest appreciation…

Dr Dave

PS Not only am I not dead, but I am growing younger as we speak!!!