In the last blog I delved into some associations between the biologic time clocks we call Telomeres, sugar control and obesity. The net summary of that blog is that the body has only so many responses to insults like high blood sugar and obesity, and those responses can wind up looking pretty much the same […]
When therapy is mistaken for normal Read More »
I read an interesting article recently. Without going into all the gory scientific details, the gist of the article was as follows: even lean diabetics may have the same metabolic profile and telomere length shortening as non-diabetic obese people, if those lean diabetics have poor sugar control. What is the big deal? Well, it means
Telomere Length and Metabolic Obesity in Skinny People Read More »
There is a 30 billion dollar industry supporting the use of statins for both primary prevention and secondary prevention (after the fact) of heart attacks. Similarly, hundreds of millions in studies have been spent to “justify the use of statins”. The JUPITER study is the most recent. I have already commented on my expectation that
Chasing the wrong rabbit – why cholesterol levels are just a distraction Read More »
Heart disease has one of the longest standing associations with short telomeres. Recently a similar association was established for strokes (thrombotic ((clot) and hemorrhagic (bleeding)). The limitations of these studies in terms of direct correlation are that they are not using modern technology to determine the shortest telomere lengths or percentage. They are still using
Telomeres and Drugs and Big Pharma Read More »
If you study the biologic time clocks in the cell, known as telomeres, and you study the enzyme that lengthens them, telomerase, you are truly learning about magic. Here are a couple of amazing things I have learned: 1) Telomeres are intimately involved with just about every longevity and health pathway known to science. 2)
Many herbal and plant-derived compounds show anti-cancer activity. Sadly, until someone figures out how to make the big drug pay day by changing them just enough to patent them, no one listens. This is especially true of doctors who forget that 90% of drugs come from “refinement” of natural sources and the other 10% that
Food for life – Broccoli and Telomeres Read More »
In my most recent blog, The Monster is Not Born Immortal, I discussed in real time the results of Dr Maria Blasco’s most recent paper using both telomerase over expression and Calorie Restriction. As usual, I got a bevy of comments, many of which were nasty grams and did not get published for that reason,
Telomere maintenance – We who are about to die Salute You Read More »
A recent German study has found an association between familial and non familial malignant melanoma and the telomerase gene. I think we should talk about this because it shows where the seemingly unending association with telomerase and cancer came/comes from. First concept: Cancer cells are not normal. They are the result not only of loss
The monster is not born immortal: When telomerase drives cancer Read More »
It may seem strange to tie all of these seemingly dissimilar things together but bear with me and all will be revealed. As you probably know by now rats share many things in common with people. Some people more than others! There are similarities in biochemistry, structure and yes, behavior – all of which makes
Rat empathy, stress and telomere shortening Read More »
Bottom line of this whole blog: Supplemental Telomerase Activation is Required for increases in Longevity whether you calorie restrict or not. There are probably three or four studies now that show one simple irrefutable fact: you must turn on and increase telomerase expression to improve longevity. Most of them have come from Maria Blasco’s lab in
Life without Twinkies – Calorie restriction and Telomerase Read More »