In my most recent blog, The Monster is Not Born Immortal, I discussed in real time the results of Dr Maria Blasco’s most recent paper using both telomerase over expression and Calorie Restriction. As usual, I got a bevy of comments, many of which were nasty grams and did not get published for that reason, […]
Telomere maintenance – We who are about to die Salute You Read More »
I had an interesting discussion with a friend of mine the other day about character, specifically strength of character. The phrase “Hard as nails” came up over and over again in almost every imaginable context: business, physicality, relationships, dealing with people, friends, family members and so on. My friend then said to me, “Doc, you
Hard as Nails versus Tough as Nails – more than a name! Read More »
A recent German study has found an association between familial and non familial malignant melanoma and the telomerase gene. I think we should talk about this because it shows where the seemingly unending association with telomerase and cancer came/comes from. First concept: Cancer cells are not normal. They are the result not only of loss
The monster is not born immortal: When telomerase drives cancer Read More »
It may seem strange to tie all of these seemingly dissimilar things together but bear with me and all will be revealed. As you probably know by now rats share many things in common with people. Some people more than others! There are similarities in biochemistry, structure and yes, behavior – all of which makes
Rat empathy, stress and telomere shortening Read More »
Bottom line of this whole blog: Supplemental Telomerase Activation is Required for increases in Longevity whether you calorie restrict or not. There are probably three or four studies now that show one simple irrefutable fact: you must turn on and increase telomerase expression to improve longevity. Most of them have come from Maria Blasco’s lab in
Life without Twinkies – Calorie restriction and Telomerase Read More »
I have said at least a dozen times, you need human studies to document the effect of something in humans! While I freely admit there are probably a dozen or so compounds that turn on telomerase in the lab, TA-65 is the only one with human studies. Recently an actual head to head study was
TA-65 demonstrates superiority in a head to head trial Read More »
Warning: this blog is long, somewhat complicated, very controversial, likely to make me enemies, likely to be 100% true and an honest reflection of my personal experience and likely to alienate anyone with a different agenda! So be it. Try to focus long enough to read it all, because it will do your telomeres a
I find myself saying the same thing over and over again and I still see the same baseless assumptions all over the internet. So, with my usual cut-through-the-BS attitude, I feel compelled to do what is necessary to protect the truth – YET AGAIN! There are several misconceptions that continue to float around in the
The Truth about Telomerase activation and Resveratrol – The Long and Winding Road Read More »
I will use the standard marketing style — “Yes, but it’s not what you think!” In order to effectively answer your question, I think we’d need to define fanatic and that of course is subject to interpretation. The obituaries are peppered with athletic superstars dying before their age. Grete Waitz died at 57 of cancer.
Does being a fitness fanatic make you live longer? Read More »
I can’t say it’s a surprise that calorie restriction has failed to extend life in higher primates. It was at least successful in flies, worms and some lower mammals. I understand it has not led to mass gorging on the part of the CR society, who bravely soldier on in the face of this recent
The sad failure of calorie restriction Read More »