It’s Amazing How Many People Don’t Know This!

Sometimes I wonder what would happen if researchers and regulators read my stuff.

If you have read my stuff then you know there is this strange phenomenon.

I say it, it gets ridiculed and several years later it gets proven as correct.

A classic example was our book The Immortality Edge.

I wrote that cellular aging was directly tied to telomeres and this was reflected in organismal aging, Scientists and lay people alike launched negative criticisms and lower star ranks on Amazon because we had “no proof”.

Now you read these words routinely: Telomeres are tied to aging, cellular and beyond. And despite the plethora of people who lately have decided to push methylation as an issue, there is nothing you can do to specifically change methylation and really there is no proof of this.

There are studies showing that lengthening telomeres adds years and health to animals’ lifespans not just years to their lives like calorie restriction. There is a big difference between extending life span and just pushing an organism towards its normal number of years in life. To do the first there are many things you can do. To do the second you have to take care of telomere length, structure, and function.

Very very recently an article was published in Molecular Cell where the lead author named Cesare said this ” “We’ve shown that it’s not just telomere length, but telomere structure and telomere health that we need to understand,”

Also stated was that “analyzing and managing the structure and behavior of the telomeres and their loop-like features could point to better ways of preventing and treating major diseases.”

The only way you never heard that before ( like for the past 8 years!) is if this is the very first time you are reading my writings. Otherwise you already know it and have known it.

So as you ponder all these facts you might want to ponder and remember to take your Immortality Edge Packs!!!
I designed these for the exact things and reasons stated in the most recent article in Molecular Cell.

Take Care Of Your Telomeres!

Dr. Dave

 

Reference: Telomere Loop Dynamics in Chromosome End Protection

Authors:David Van Ly, Ronnie Ren Jie Low6, Sonja Frölich7, Tara K. Bartolec8, Georgia R. Kafer, Hilda A. Pickett, Katharina Gaus, Anthony J. Cesare https://doi.org/10.1016/j.molcel.2018.06.025
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Telomeres- Current State of the Art

It’s probably been two years since I asked my friend and quintessential telomere scientist Bill Andrews what he found most heartening and most disappointing about the telomere/telomerase field.

We were recording a telecon together and I am not sure if it ever really got aired as the individuals responsible for that aspect of things proved not to be particularly reliable among other things.

But while Bill and I both enjoyed the fact that the field has progressed and the measurement aspect of telomeres had matured with companies like Life Length (enough of you took advantage of that special I ran on the test to keep me very busy LOL), we both lamented the usurpation of the longevity aspect of telomeres by the cancer field.

The usual scenario goes something like this: many human cancers express telomerase so we are going to focus on this enzyme to create drugs to stop cancer. It won’t work because cancer is not a single gene problem in most cases.

There are tons of known oncogenes you no longer hear about. HIF-1 alpha. C Myc, KRAS, ATM. P53 to name a few.

In all of the above cases there are cancers that express these genes and many others. The cocktail approach involves sampling a tumor, finding the aberrant, over expressed or mutated genes and then trying to block them. Telomerase over expression or mutation is in that ilk. But tumors have a way of changing the genes needed to keep them going and telomerase is only one in series of events that needs to happen.

Simply put we still don’t know what causes cancer. My suggestions to further explore mitochondrial and metabolic drivers are not being followed, at least at any significant level.

What might happen with telomerase inhibitors which so far have not delivered on their promise, is you might buy a little time or runway until the tumor figures out its next step and comes back worse than ever.

Most of the gene products and gene interventions I mentioned above failed to produce viable drugs either.

But top-level scientists continue to insist that prevention is waste of time.
I beg to differ!!!

While I could never publicly suggest that keeping your telomeres long and healthy  and combatting inflammation in your body might help you.

I can tell you to go to pub med and look at what happens to telomeres in cancer and aging. I can ask you to look at what happens to cancerous tumors when you add Omega 6 inflammatory fats and conversely at Omega 3 fish oil type fats.

Then you can decide for yourself.

I have not lost my passion for telomeres and telomerase. I simply have to watch the powers that be make all the mistakes, follow the wrong path, and gouge us for money in the process.

You however don’t have to wait!!!

Dr Dave

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Just a Simple Thank You

I am a firm believer in appreciation.

So, I wanted to thank you for making the introduction of my new telomere product a huge success.

Apparently, it really was true people were waiting for the replacement to the Telomere Edge Packs of old.

You may have noticed the new product, The Immortality Edge Packs bears the same name as the book I wrote way back in 2010.

Learning is a continuous process and I am not clairvoyant but every day I see more and more and more evidence that the telomere is the most important gateway to longer life and health although not the only one.

As I have said before, much to the chagrin of my critics, the information in that book is if anything, “more true” even than it was 8 years ago.

I also see the expected, I suppose blow back against anything that might achieve those goals. The most recent government interest in all things anti-aging including the restrictive approach to stem cell therapeutics in the United States, and the wide spread legal action against clinics and researchers (this started long before the current administration!) is the fall out for the progress we’ve made.

Oh well, I guess if it weren’t worth trying to regulate and legislate, it wouldn’t be worth anything at all.

Still, I appreciate your personal desire to make a difference in your own life as I do in mine.

We are kindred spirits.

Also, thanks to all of you who wrote in mentioning the book, The Immortality Edge as well as the telomere based products.

Like you, I am my own engine. But its sure nice to be appreciated.

Thanks for sticking with me!!!

 

Best,

Dr Dave.

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Tammi’s Revenge!!!

Boy did I just get an ear full!

Tami is a long time customer- like in since 2003!

Apparently, she was out of the country until this Monday and completely missed the Immortality Edge Pack intro.

And she was not the only one, she was just the most vociferous.

And she was equally pissed at missing the Life Length Telomere Test Deal (see below).

“ I have been waiting for the price to come down to do this and now you yank it back!” she said only half joking.

Now you can’t put a price on loyalty, and you can’t beat a super accurate, repeatable telomere assay that tells you your true Biologic Age!

But honestly THIS IS IT!  I can’t put off the inevitable so this is the LAST DAY to get both the new Packs and the Life Length Telomere Test (also known as TAT).

Then we got to go to retail pricing on both!

Now, in case you forgot, I arranged for a special deal for you on Telomere Testing with my friends in Madrid at Life Length.

Lot’s of people have asked me about measuring their telomeres before they start therapies. I have always thought that is a fantastic idea. And now that I have a new “telomere centric” product I encourage you to take the Life Length test because its at the best possible price I could arrange for you and you really SHOULD KNOW where you stand.

Normally this test would cost you a minimum of $600 depending on where you get it done. In Southern California its often closer to $1000! These fees include the test and the doctors interpretation.

But since I have probably done more interpretations than any other single physician out there I thought, “Why not donate my time, encourage YOU to get the test and have a great chance to talk one on one with you when the results are ready!!!”  So if you buy the product you get a special code to save big on the test.  The price has been reduced to $320* which is almost 50% less than what you would pay ANYWHERE in the U.S.

AND you get an hour of my time free to go over the test one on one with me.  A little secret: I don’t set a timer so sometimes we go longer and talk about all kinds of things after we are done with the telomeres!

It’s actually one of the most fun things a I do and everyone that does it with me universally says it was far more than they could have expected. And remember this is the one and only test that can predict your true cellular biologic age (functionally how old your cells are).

So, get the product and take the test!!!!**

Here is what you do:

Once you’ve ordered your Longevity Edge Packs at the special pricing you email mailto: [email protected]    Put USDRDV in the subject line, that is your special savings code.

A very nice smart young man named Michael will get back to you via email and other if needed and make sure you get this special savings for my customers only!

And take advantage of everything I have learned in the past 8 years and give your body the upgrade it deserves!!!

Limited Time Only!!!

The one and only Dr. Dave who by the way is really really really looking forward to discussing your telomere results with you.

PS You may want to check out the FAQ’s page and ingredients which will tell you the main differences between this and the old product but one big thing is the packet is much simpler to take- its 3 caps and can be taken as little as once a day!

PSS as you can probably tell this announcement is for my best loyal long-time customers because only YOU know the importance of telomeres to health and longevity.  Newbies will have to read all the stuff I have written for the past 8 years. You already know it!

*This is a blood test. You will need to have your blood drawn.  You can arrange for a phlebotomist yourself or through your local doctor’s office if you like. Or Life Length can make those arrangements for you with a mobile phlebotomy service for an additional $50.  To get your test you will pay them not me- my time to you is free. I can email your results to your physician if you like and provide me with an email address. The kit comes with everything you need to send your blood including the correct tubes and pre paid airbill.  You just need to have someone draw it for you. Allow 3-4 weeks to get the results back.

** Telomeres do not change rapidly so its OK for you to get the pack and start the supplements.  If you get your test done within the first 2 months it would still be considered “baseline” as if you had not taken anything.

PSS if you want to see how simple the test is to do you can see me do it here.

Just remember I am no longer Dr Dave’s Best,  I am www.TheLongevityEdge.com only  Don’t get confused by the old logo!

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Don’t Miss This Chance to Save Big on My Telomere Product!!!!

We are closing in on closing the Introductory Sale of the Immortality Edge Packs.

These are not just upgrades on the old product, they are whole new ball game and designed, manufactured and sold by me- not imposters!!!

Also I have arranged for special pricing with Life Length so you can have your telomere length tested but this offer is tied to the Introductory sale offer of the Immortality Edge Packs.

The introductory sale is only available until close of business TODAY and then we go to retail only.

The old Telomere Edge Packs were super popular and often sold out. But it’s time to upgrade and get rid of the old and in with the new.

 

Lots of people have asked me about measuring their telomeres before they start therapies. I have always thought that is a fantastic idea. And now that I have a new “telomere centric” product I encourage you to take the Life Length test because its at the best possible price I could arrange for you and you really SHOULD KNOW where you stand.

Normally this test would cost you a minimum of $600 depending on where you get it done. In Southern California its often closer to $1000! These fees include the test and the doctors interpretation.

But since I have probably done more telomere interpretations than any other single physician out there I thought, “Why not donate my time, encourage YOU to get the test and have a great chance to talk one on one with you when the results are ready!!!”  So if you buy the product you get a special code to save big on the test.  The price has been reduced to $320* which is almost 50% less than what you would pay ANY
WHERE in the U.S.

AND you get an hour of my time free to go over the test one on one with me.  A little secret: I don’t set a timer so sometimes we go longer and talk about all kinds of things after we are done with the telomeres!

It’s actually one of the most fun things a I do and everyone that does it with me universally says it was far more than they could have expected. And remember this is the one and only test that can predict your true cellular biologic age (functionally how old your cells are).

So, get the product and take the test!!!!**
Here is what you do:

Once you’ve ordered your Longevity Edge Packs at the special pricing you email mailto: [email protected]    Put USDRDV in the subject line, that is your special savings code.

A very nice smart young man named Michael will get back to you via email and other if needed and make sure you get this special savings for my customers only!

And take advantage of everything I have learned in the past 8 years and give your body the upgrade it deserves!!!

Limited Time Only!!!

The one and only Dr. Dave who by the way is really really really looking forward to discussing your telomere results with you.

 

Doc

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The Immortality Edge Packs are Here Now!!!

Just a reminder my new telomere specific supplement is here and in stock now.  Its also at the best price possible for the next 24 hours so take advantage and don’t miss out.

It’s newer better and totally redesigned to reflect all the knowledge I have gained since publishing the “Immortality Edge” book in 2010 and the original Telomere Edge packs which I no longer make, 2012.

Everything has been changed and upgraded and its now 1 pack a day instead of 2.

Order your Immortality Edge packs now!

 

The real Dr Dave!

PS If you missed the launch email which also details a hugely discounted telomere test with Life Length, go here!

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FAQ’s and Ingredients on the NEW Immortality Edge Packs

First off let me thank Ben G for pointing out a clumsy move on my part!

The ingredients panel for the new Immortality Edge Packs is in the FAQ sections which somehow got buried in the site map below the copy.

Thanks Ben and my apologies to anyone who was looking for the new ingredients and more info on the product before buying.

All I can do is remind you I am a great doctor but not always so great at the business end of things lol!

Either way check out my newest baby and reap the rewards!

Dr Dave

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Announcing My New And Upgraded Telomere Specific Supplement-The Immortality Edge Packs

First, I need to ask you to indulge me and read this whole email including the PS and the asterisks below the PS because there are 2 BIG THINGS that I don’t want you to miss!

First: Out with the Old and in with New!

That saying applies to supplements from time to time as well.

It has been over 6 years since I created a new Telomere Specific Supplement but the day has finally arrived!

The Immortality Edge Packs are now in stock and believe me it’s none too soon.

I worked diligently on the formulation for a long, long time and it is totally revamped and redone and shares very little in common with the old formula which I designed back in 2012.  Hey, it was a good product, but things have changed, science has advanced and it was time for an update and a makeover!

The Immortality Edge Packs are available in single canister pricing but notice as usual you can Save Big on Subscription/Continuity, and even more by grabbing an entire case!

We expect to sell out quickly so find out more here and then hit the “buy” button because you don’t want to be left out and placed on back order.

The introductory sale is only available until Friday close of business and then we go to retail only. Keeping in the style of my product launches, today is the absolute best pricing EVER on these!

The old Telomere Edge Packs were super popular and often sold out. But it’s time to upgrade and get rid of the old and in with the new.

Next, I arranged for a special deal for you on Telomere Testing with my friends in Madrid at Life Length to go hand-in-hand with my new Telomere Specific Supplement launch.

Lot’s of people have asked me about measuring their telomeres before they start therapies. I have always thought that is a fantastic idea. And now that I have a new “telomere centric” product I encourage you to take the Life Length test because it’s at the best possible price I could arrange for you and you really SHOULD KNOW where you stand.

Normally this test would cost you a minimum of $600 depending on where you get it done. In Southern California its often closer to $1000! These fees include the test and the doctors interpretation.

But since I have probably done more interpretations than any other single physician out there I thought, “Why not donate my time, encourage YOU to get the test and have a great chance to talk one on one with you when the results are ready!!!”  So if you buy the product you get a special code to save big on the test.  The price has been reduced to $320* which is almost 50% less than what you would pay ANYWHERE in the U.S.

AND you get an hour of my time free to go over the test one on one with me.  A little secret: I don’t set a timer so sometimes we go longer and talk about all kinds of things after we are done with the telomeres!

It’s actually one of the most fun things a I do and everyone that does it with me universally says it was far more than they could have expected. And remember this is the one and only test that can predict your true cellular biologic age (functionally how old your cells are).

So, get the product and take the test!!!!**

 

Here is what you do:

Once you’ve ordered your Immortality Edge Packs at the special pricing you email [email protected]    Put USDRDV in the subject line, that is your special savings code.

A very nice smart young man named Michael will get back to you via email and other if needed and make sure you get this special savings for my customers only!

And take advantage of everything I have learned in the past 8 years and give your body the upgrade it deserves!!!

Limited Time Only!!!

The one and only Dr. Dave who by the way is really really really looking forward to discussing your telomere results with you.

PS You may want to check out the FAQ’s page and ingredients which will tell you the main differences between this and the old product but one big thing is the packet is much simpler to take- its 3 caps and can be taken as little as once a day!

PSS as you can probably tell this announcement is for my best loyal long-time customers because only YOU know the importance of telomeres to health and longevity.  Newbies will have to read all the stuff I have written for the past 8 years. You already know it!

*This is a blood test. You will need to have your blood drawn.  You can arrange for a phlebotomist yourself or through your local doctor’s office if you like. Or Life Length can make those arrangements for you with a mobile phlebotomy service for an additional $50.  To get your test you will pay them not me- my time to you is free. I can email your results to your physician if you like and provide me with an email address. The kit comes with everything you need to send your blood including the correct tubes and pre paid airbill.  You just need to have someone draw it for you. Allow 3-4 weeks to get the results back.

** Telomeres do not change rapidly so its OK for you to get the pack and start the supplements.  If you get your test done within the first 2 months it would still be considered “baseline” as if you had not taken anything.

PSS if you want to see how simple the test is to do you can see me do it here.

Just remember I am no longer Dr Dave’s Best,  I am www.TheLongevityEdge.com only  Don’t get confused by the old logo!

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Dr. Dave Woynarowski Telomeres – Singing the Tune

I wrote my portion of the Immortality Edge months before its release in late 2010. It was an interesting experience as no one really knew what to do with the information-even though we spelled it out!

My co authors Mike Fossel and Greta Blackburn gave exercise recommendations. Subsequently the positive effect of exercise on telomere length was demonstrated multiple times.  We told you what to eat.  Subsequently the positive effect of diet was demonstrated many times.  We told you what supplements to take including Pharmaceutical Grade Fish Oil.

We also told you to keep your eye on this space because amazing things would be happening and that we were for the first time in human history really on to something.  I showed you how I grew my own telomere length over 1200 base pairs in 2-3 years and validated it with 3 separate telomere tests including the most valid.

Other things I told you about were high fat low carb diets, fish oil and telomeres and longevity, stem cells and inflammation modulation, sleep and its effect on your cells and how you age.

Now I am not going to stomp my feet and cry out loud that no one is listening to me but I will say this: all the people who wrote negative reviews of our book on Amazon never came back and admitted we were right.

Not one.

So what has happened since then?

Since then I have seen the emergence of tons of “new thought leaders” who I never heard of.  Of those I did know of beforehand, more than one of them were critical of my writings over the past years in public.

Now they all seem to be singing the “Telomere Tune”.  I gave a recent speech at the A4M Orlando on lifestyle and its effect on telomere length.  Do you realize it has been 7 years since they asked me to speak on this topic?

I have my theories on why that is related to the fact that I “sell things on the internet” but let me tell you something.  Selling those things on the internet has put me into a position where I can now afford to do some studies and research that I have not been able to do in the past including working with BioStem Technologies. So for all of you who have been loyal supporters over the past decade and a half and of course my new friends, I thank you.

Dr. Dave Woynarowski will continue to be a telomere guinea pig so you don’t have to.

I make the same promise I made back then- I will continue to bring you what really works. I will continue to be a guinea pig so you don’t have to and I will not recommend anything for you I do not use myself.

Have any of those famous TV gurus you’ve seen said that to you?

Now here is the tough part. As much as I want you to live the longest healthiest life you can I am not going to argue with you or try to convince you.  In the words of rapper Sweet Brown, I ain’t got time fo’dat!!!!

Frankly I would be doing what I do for myself and a few loved ones even if no one knew who I was.

But the good news is you can come along.

This coming week I will update you more on the telomere story.

 

Til’ then keep Singin’!!!!

Doc

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Telomerase and Cancer Part 8

Yes it’s true I have written 8 different articles about cancer and telomerase since 2009 and I suppose I should prepare to write 8 more.

The most recent stir up in the field came from an internet news blitz entitled “Long Telomeres May Increase Cancer Risk” detailing the findings of an erudite Southern California lab based at the same University as Telomere Nobel Laureate Elizabeth Blackburn.

This group has major scientific star power and lots of science cred to back up what they say.

Naturally the “see we told you so” crowd picked up on this immediately and interpreted it as Telomerase causes cancer. The more they dislike me and what I do or the more I pissed them off in the past for not buying into what they are doing the more vociferous the email nasty grams.

One person even suggested “Your telomerase activators are giving people cancer and your book is full of deadly information!”

So after a week or so of this I did what it seems I have to do more and more often these days. Break my vow of silence and answer the questions directly all the while trying to remain nice, calm and objective.

So here is the background.

In this particular study the scientists were looking at a rare and deadly tumor known as glioma (there are several different forms of this brain cancer and none are good!).

They found an association with long telomeres and glioma and used a technique known as Genome Wide Association Study (GWAS) to establish a link to mutations “in the area of the telomerase gene” that “might “ account for the increases in Glioma they saw.

Using my least favorite way of determining telomere length QPCR they found said association in 3 different areas “related” to the telomerase gene.

More background: the telomerase gene and other “longevity genes” such as APO and glucose/insulin genes are located in areas that are hypermutatable for lack of a better term.  This means that more mutations than expected are found in these areas than many other areas of the genome.

The reason for this is unknown but please understand it is a well documented and rather widespread phenomenon that is not limited to the telomerase gene.

These mutations are called SNPs or single nucleotide polymorphisms because the result in one change in one molecule of DNA.

Please understand that SNPs are a favorite of scientists studying cancer and other diseases because if they can reproduce them in animal models then they can study the cancer that way. At the same time it is likely that most human cancers do not occur as SNPs but rather as epigenetically driven changes.

Even the most famous BRAC SNPs associated with breast cancer are estimated to account for 5% or less of human cancers. Put another way 95% of breast cancer is not due to these SNPs.

Also understand that SNPs are often inherited meaning the changes they cause in the genome are present from the time of conception until death. In terms of the SNPs that are associated with glioma they occur in the general population  between 50 and 70% of the time and are present in over half of the control group which is 4x larger than the cancer group. That control group did not get cancer.

Glioma is also associated with older age at the time of onset.  The older you are the more likely you are to get glioma. The control group that has no cancer and longer telomeres is likely to live considerably longer than an equal group with short telomeres.

Gliomas are also well known to use the ALT non telomerase method to lengthen their telomeres rather than increasing telomerase.

So here is my list of questions for the authors:

Why did you use QPCR the least accurate method of measuring MTL which misrepresents telomere dynamics and introduces a large potential for inaccuracy? My guess is once we get past all the other political stuff would be “Because that is what lots of other people are using!”

Next when does a SNP become considered normal?  If it’s present in over half of the population at large then how do we know it’s a mutation.

Finally did they factor in age at diagnosis as an independent risk factor since gliomas go up with age.

Now the truth is they did not need to look at all this stuff because they were not saying Telomerase Causes Cancer or Long Telomeres Cause Cancer ( again JAMA Dec 2010 showed exactly the opposite: short telomeres are associated with cancer!). They were saying mutations in the area of the telomerase gene are ASSOCIATED with one rare Cancer.

Big difference.

Especially when you consider that genetic mutations are forever and for life in many cases and cause elevations of gene products as well as dysfunctions of gene products that are not associated with short term telomerase activators.

In addition there is no data to suggest that using supplements like fish oil which appears to preserve telomere length, or TA-65 which may lengthen telomeres has ANY association with cancer of ANY kind in.

I applaud the scientific discoveries made by scientists and of course the use of GWAS is interesting in looking at SNPs. But I remind you the word associated does not mean cause. You could potentially find that eating pizza is associated with a higher death rate in motor vehicle accidents.

And we went through this last summer when a study cited a 2% change in Omega 3 levels as associated with a 73% increase in prostate cancer.

For most of us SNPs are the least of our worries. Shortening telomeres on the other hand is a 100% given. Read some of the other myths about telomeres and telomere supplementation here.

 

 

Doc

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